629: Anticoagulation and Transfusion Management of Children on Extracorporeal Membrane Oxygenation

Endogenous glycosaminoglycan anticoagulation in extracorporeal membrane oxygenation

A heparin-like effect was recently described in infants, children, and adults receiving bivalirudin while supported on extracorporeal membrane oxygenation following cardiopulmonary bypass. This is most likely due to endogenous release of glycosaminoglycans from vascular endothelium and mast cells and is associated with longer duration of extracorporeal membrane oxygenation and an increased inci...

HEMOSTASIS AND ANTICOAGULATION MONITORING DURING EXTRACORPOREAL MEMBRANE OXYGENATION IN CHILDREN by

Thromboelastography-based anticoagulation management during extracorporeal membrane oxygenation: a safety and feasibility pilot study

BACKGROUND There is no consensus on the management of anticoagulation during extracorporeal membrane oxygenation (ECMO). ECMO is currently burdened by a high rate of hemostatic complications, possibly associated with inadequate monitoring of heparin anticoagulation. This study aims to assess the safety and feasibility of an anticoagulation protocol for patients undergoing ECMO based on thromboe...

Management considerations of massive hemoptysis while on extracorporeal membrane oxygenation.

BACKGROUND Veno-arterial extracorporeal membrane oxygenation (V-A ECMO) is a life-saving procedure in patients with both respiratory and cardiac failure. Bleeding complications are common since patients must be maintained on anticoagulation. Massive hemoptysis is a rare complication of ECMO; however, it may result in death if not managed thoughtfully and expeditiously. METHODS A retrospective...

Extracorporeal Membrane Oxygenation

Cerebral perfusion temperatures during antegrade cerebral perfusion and their affect on cerebral metabolism and neurological outcomes are evaluated in this study. Young piglets were subjected to a period of hypothermic circulatory arrest at 20°C using alphastat pH management. Four study groups were then assigned to differing temperatures of selective cerebral perfusion. Lower perfusion temperat...